RUNWISE
Biotech risk research

Biotech risk, scored by how long a company can last.

Runwise ranks biotech and life science tools stocks on three things: money in the bank, strength of the pipeline, and where the industry is heading. It is a student research project.

Data as of June 30, 2026 filings (Q2 2026). Not investment advice. Stage, program count, team rating, and industry outlook are analyst judgments.
Section 1

Two ways to judge a biotech

Clinics and investors look at the same company with different goals. Runwise tries to respect both.

What research clinics look for

They ask if a study can be run safely and finished.

  • Safety proof from lab and animal work before humans are dosed
  • Clear, measurable endpoints like tumor size or a biomarker
  • Simple trial rules and patients who can actually be enrolled
  • A sponsor with enough cash to pay sites and survive delays
  • Regulatory basics in place, such as an IND and IRB approval

What investors look for

They ask if the company can earn a return.

  • The science and how the drug works at a molecular level
  • Data quality: sample size and statistical significance
  • Pipeline depth, so one failure does not sink the company
  • Market size and unmet medical need
  • Cash runway and burn rate before more dilution
  • Patent protection and exclusivity
  • Risk adjusted value (rNPV), which weighs future cash by odds of success

Where they overlap

Both sides care about cash runway and pipeline depth. A clinic does not want a sponsor that runs dry mid trial. An investor does not want to be diluted. That overlap is why those two ideas carry most of the weight in this model.

Section 2

Methodology

Each pillar is scored 0 to 100. The final score is a weighted average. Higher means lower risk.

Financial health

runway = cash / (quarterly burn / 3)
Score = runway divided by 36 months, capped at 100. Burn uses operating cash use where found. Beam uses net loss as a proxy.

Pipeline and product maturity

Stage 1 to 5 (50%), number of programs (20%), platform and team rating (30%).

Industry outlook

A 1 to 10 judgment of demand and funding trends for the company's market, times 10.

40%
40%
20%

Weights rescale to 100% and the ranking updates.

Section 3

Scoreboard

Scores compare the selected companies to each other. They are not absolute grades.

Pick companies to compare

Add any company

Enter figures from the company's latest filing, in $ millions. Burn is operating cash used per quarter. Type a ticker and press Look up to fill the name, cash, and burn from the latest SEC filing. Then set the four judgment fields yourself. Added companies are saved in this browser only.

Dark to light segments: financial, pipeline, industry. Each shows its weighted contribution.

Section 4

Company deep dives

Runway estimates use the same cash and burn inputs as the scoreboard.

Section 5

The capex lens

Capex is money spent on equipment and buildings. For a biotech it shows how much cash goes into physical capacity instead of research. Heavy capex can shorten runway fast. Low capex can mean a lean lab or a company that outsources.

CompanyCapex foundWhat it suggests
Nautilus (NAUT)About $1.3M in FY2025. Gross property and equipment rose about $1.1M in H1 2026 (from $11.6M to $12.7M).Very light. Under 3% of yearly cash use. The cash goes to R&D, not buildings.
Quantum-Si (QSI)$0.3M in Q1 2026.Light, but it plans inventory investments ahead of the Proteus launch.
Recursion (RXRX)Not included.Capex was not part of the figures reviewed for this company.
Beam (BEAM)Not included.Beam says it is building internal manufacturing, so capex is a key number to watch.
Section 6

Limits

  • Runway ignores new fundraising, partner payments, and dilution.
  • Stage, program count, platform rating, and industry outlook are judgment calls, not reported facts.
  • Two of the four built-in companies sell tools, not drugs, so stage means launch readiness for them.
  • Four companies are built in. Live lookup fills cash and burn from SEC filings, and the four judgment ratings are always entered by hand.
  • Built in figures reflect Q2 2026 filings. Live lookup uses each company's latest filing on record, and prices are delayed.
Section 7

Sources

Section 8

About

Alsadig Bashir
Purdue University

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